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On the other hand when the heat killed capsulated virulent smooth cells were mixed with non-virulent rough cells D and then were injected in the mice the disease was produced. This shows that some factors from the dead capsulated smooth cells, converted the living non-virulent rough cells into living smooth capsulated virulent cells, see fig. They found that the DNA isolated from the heat killed smooth cells, when added to rough cells changed their surface character from rough to smooth, and also made them virulent. By this experiment, this was shown that DNA was the genetic material responsible for inducing the smooth character of the cells and their property of virulence in mice.